Issues in performance evaluation for host–pathogen protein interaction prediction
نویسندگان
چکیده
منابع مشابه
Issues in performance evaluation for host-pathogen protein interaction prediction
The study of interactions between host and pathogen proteins is important for understanding the underlying mechanisms of infectious diseases and for developing novel therapeutic solutions. Wet-lab techniques for detecting protein-protein interactions (PPIs) can benefit from computational predictions. Machine learning is one of the computational approaches that can assist biologists by predictin...
متن کاملPrediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks
Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...
متن کاملPrediction Accuracy Evaluation of Domain and Domain Combination Based Prediction Methods for Protein-Protein Interaction
Since the proposal of domain based protein-protein interaction prediction method by [3], there are many attempts to improve domain based protein-protein interaction prediction methods [1]. Among them, domain combination based protein-protein interaction method by [2] is quite appealing in the sense that it achieves very impressive prediction accuracy in some situations. However there is no conc...
متن کاملComputational Methods for Protein-Protein Interaction Prediction
Protein-protein interactions (PPI) occur at almost every level of cell functions. The identification of interactions among proteins provides a global picture of cellular functions and biological processes. It is also an essential step in the construction of PPI networks for human and other organisms. PPI prediction has been considered to be a promising alternative to the traditional drug design...
متن کاملProtein Interaction Networks: Protein Domain Interaction and Protein Function Prediction
Most of a cell’s functional processes involve interactions among proteins, and a key challenge in proteomics is to better understand these complex interaction graphs at a systems level. Because of their importance in development and disease, protein-protein interactions (PPIs) have been the subject of intense research in recent years. In addition, a greater understanding of PPIs can be achieved...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bioinformatics and Computational Biology
سال: 2016
ISSN: 0219-7200,1757-6334
DOI: 10.1142/s0219720016500116